| Drug-Target Information | ||||||||
|---|---|---|---|---|---|---|---|---|
| Drug Name | Target Name | Drug Type | Target Type | Source | Drug MeSHID | Interaction Score | Drug Status | Target Action |
| tretinoin | retinal dehydrogenase 1 | small molecule | NA | drugbank | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational,nutraceutical | unknown |
| tretinoin | retinal dehydrogenase 2 | small molecule | NA | drugbank | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational,nutraceutical | unknown |
| tretinoin | cytochrome p450 26a1 | small molecule | NA | drugbank | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational,nutraceutical | unknown |
| tretinoin | cytochrome p450 26b1 | small molecule | NA | drugbank | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational,nutraceutical | unknown |
| tretinoin | cytochrome p450 26c1 | small molecule | NA | drugbank | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational,nutraceutical | unknown |
| tretinoin | retinoic acid-induced protein 3 | small molecule | NA | drugbank | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational,nutraceutical | unknown |
| tretinoin | hematopoietic prostaglandin d synthase | small molecule | NA | drugbank | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational,nutraceutical | unknown |
| tretinoin | lipocalin-1 | small molecule | NA | drugbank | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational,nutraceutical | unknown |
| tretinoin | odorant-binding protein 2a | small molecule | NA | drugbank | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational,nutraceutical | unknown |
| tretinoin | [pyruvate dehydrogenase [lipoamide]] kinase isozyme 4, mitochondrial | small molecule | NA | drugbank | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational,nutraceutical | unknown |
| tretinoin | retinoic acid receptor alpha | small molecule | NA | drugbank , DGIDB | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
0.5 | approved,investigational,nutraceutical | agonist |
| tretinoin | retinoic acid receptor alpha | small molecule | NA | drugbank , DGIDB | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
0.5 | approved,investigational,nutraceutical | unknown |
| tretinoin | retinoic acid receptor beta | small molecule | NA | drugbank , DGIDB | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
0.39 | approved,investigational,nutraceutical | agonist |
| tretinoin | retinoic acid receptor gamma | small molecule | Successful target | TTD , drugbank , DGIDB | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
1.36 | approved,investigational,nutraceutical | agonist |
| tretinoin | retinoic acid receptor responder protein 1 | small molecule | NA | drugbank , DGIDB | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
5.79 | approved,investigational,nutraceutical | agonist |
| tretinoin | retinol-binding protein 4 | small molecule | NA | drugbank | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational,nutraceutical | unknown |
| tretinoin | retinoic acid receptor rxr-alpha | small molecule | NA | drugbank , DGIDB | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
0.05 | approved,investigational,nutraceutical | unknown |
| tretinoin | retinoic acid receptor rxr-beta | small molecule | NA | drugbank , DGIDB | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
1.5 | approved,investigational,nutraceutical | agonist |
| tretinoin | retinoic acid receptor rxr-gamma | small molecule | NA | drugbank , DGIDB | Skin Wrinkling[MeSHID:D015595] Palmoplantar Keratosis[MeSHID:D007645] Ichthyosis Vulgaris[MeSHID:D016112] Acne Vulgaris[MeSHID:D000152] Senility[MeSHID:D000375] Hyperkeratosis Epidermolytic[MeSHID:D017488] Psoriasis[MeSHID:D011565] Keratosis Follicularis[MeSHID:D007644] Basal cell carcinoma[MeSHID:D002280] Actinic keratosis[MeSHID:D055623] Dermatologic disorders[MeSHID:D012871] Keratoderma Palmoplantar Diffuse[MeSHID:D015776] Seborrheic keratosis[MeSHID:D017492] Hyperpigmentation[MeSHID:D017495] Warts[MeSHID:D014860] Congenital Nonbullous Ichthyosiform Erythroderma[MeSHID:D017490] Acute Promyelocytic Leukemia[MeSHID:D015473] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
1.69 | approved,investigational,nutraceutical | agonist |
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