Drug-Target Information
Drug Name Target Name Drug Type Target Type Source Drug MeSHID Interaction Score Drug Status Target Action
tazemetostat histone-lysine n-methyltransferase ezh1 small molecule NA drugbank Sarcoma
Epithelioid[MeSHID:D012509]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Brain[MeSHID:D001921]
Diffuse Large B-Cell Lymphoma[MeSHID:D016403]
Rhabdoid Tumor[MeSHID:D018335]
Malignant Neoplasms[MeSHID:D009369]
synovial sarcoma[MeSHID:D013584]
Central Nervous System Neoplasms[MeSHID:D016543]
Lymphoma
Follicular[MeSHID:D008224]
Mesothelioma[MeSHID:D008654]		 NA approved,investigational inhibitor
tazemetostat histone-lysine n-methyltransferase ezh2 small molecule NA drugbank , DGIDB Sarcoma
Epithelioid[MeSHID:D012509]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Brain[MeSHID:D001921]
Diffuse Large B-Cell Lymphoma[MeSHID:D016403]
Rhabdoid Tumor[MeSHID:D018335]
Malignant Neoplasms[MeSHID:D009369]
synovial sarcoma[MeSHID:D013584]
Central Nervous System Neoplasms[MeSHID:D016543]
Lymphoma
Follicular[MeSHID:D008224]
Mesothelioma[MeSHID:D008654]		 14.32 approved,investigational inhibitor
tazemetostat enhancer of zeste homolog 2 NA Successful target TTD , DGIDB Sarcoma
Epithelioid[MeSHID:D012509]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Brain[MeSHID:D001921]
Diffuse Large B-Cell Lymphoma[MeSHID:D016403]
Rhabdoid Tumor[MeSHID:D018335]
Malignant Neoplasms[MeSHID:D009369]
synovial sarcoma[MeSHID:D013584]
Central Nervous System Neoplasms[MeSHID:D016543]
Lymphoma
Follicular[MeSHID:D008224]
Mesothelioma[MeSHID:D008654]		 14.32 approved inhibitor
tazemetostat enhancer of zeste homolog 2 NA Successful target TTD , DGIDB Sarcoma
Epithelioid[MeSHID:D012509]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Brain[MeSHID:D001921]
Diffuse Large B-Cell Lymphoma[MeSHID:D016403]
Rhabdoid Tumor[MeSHID:D018335]
Malignant Neoplasms[MeSHID:D009369]
synovial sarcoma[MeSHID:D013584]
Central Nervous System Neoplasms[MeSHID:D016543]
Lymphoma
Follicular[MeSHID:D008224]
Mesothelioma[MeSHID:D008654]		 14.32 approved unknown
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