Drug-Target Information
Drug Name Target Name Drug Type Target Type Source Drug MeSHID Interaction Score Drug Status Target Action
simvastatin histone deacetylase 2 small molecule NA drugbank Diabetes Mellitus[MeSHID:D003920]
Peripheral Vascular Diseases[MeSHID:D016491]
Cardiovascular Diseases[MeSHID:D002318]
Arteriosclerosis[MeSHID:D001161]
Stable angina[MeSHID:D060050]
Myocardial Infarction[MeSHID:D009203]
Cerebrovascular Disorders[MeSHID:D002561]
Dyslipidemias[MeSHID:D050171]
Hypercholesterolemia[MeSHID:D006937]
Hypertriglyceridemia[MeSHID:D015228]
Prescription of drug (procedure)[MeSHID:D011307]
Hyperlipidemia[MeSHID:D006949]
Coronary heart disease[MeSHID:D003327]
Cerebrovascular accident[MeSHID:D020521]
Homozygote[MeSHID:D006720]
Heart[MeSHID:D006321]
Atherosclerosis[MeSHID:D050197]
Heterozygote[MeSHID:D006579]
Hypercholesterolemia
Familial[MeSHID:D006938]
Coronary Arteriosclerosis[MeSHID:D003324]
Disease[MeSHID:D004194]
Acute Coronary Syndrome[MeSHID:D054058]
Peripheral Arterial Diseases[MeSHID:D058729]
Hyperlipoproteinemia Type IV[MeSHID:D006953]
Hyperlipoproteinemia Type III[MeSHID:D006952]
Chronic Kidney Diseases[MeSHID:D051436]
Aortic Aneurysm
Abdominal[MeSHID:D017544]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]		 NA approved inhibitor
simvastatin hmg-coa reductase NA Successful target TTD , DGIDB Diabetes Mellitus[MeSHID:D003920]
Peripheral Vascular Diseases[MeSHID:D016491]
Cardiovascular Diseases[MeSHID:D002318]
Arteriosclerosis[MeSHID:D001161]
Stable angina[MeSHID:D060050]
Myocardial Infarction[MeSHID:D009203]
Cerebrovascular Disorders[MeSHID:D002561]
Dyslipidemias[MeSHID:D050171]
Hypercholesterolemia[MeSHID:D006937]
Hypertriglyceridemia[MeSHID:D015228]
Prescription of drug (procedure)[MeSHID:D011307]
Hyperlipidemia[MeSHID:D006949]
Coronary heart disease[MeSHID:D003327]
Cerebrovascular accident[MeSHID:D020521]
Homozygote[MeSHID:D006720]
Heart[MeSHID:D006321]
Atherosclerosis[MeSHID:D050197]
Heterozygote[MeSHID:D006579]
Hypercholesterolemia
Familial[MeSHID:D006938]
Coronary Arteriosclerosis[MeSHID:D003324]
Disease[MeSHID:D004194]
Acute Coronary Syndrome[MeSHID:D054058]
Peripheral Arterial Diseases[MeSHID:D058729]
Hyperlipoproteinemia Type IV[MeSHID:D006953]
Hyperlipoproteinemia Type III[MeSHID:D006952]
Chronic Kidney Diseases[MeSHID:D051436]
Aortic Aneurysm
Abdominal[MeSHID:D017544]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]		 1.24 approved unknown
simvastatin 3-hydroxy-3-methylglutaryl-coenzyme a reductase small molecule NA drugbank , DGIDB Diabetes Mellitus[MeSHID:D003920]
Peripheral Vascular Diseases[MeSHID:D016491]
Cardiovascular Diseases[MeSHID:D002318]
Arteriosclerosis[MeSHID:D001161]
Stable angina[MeSHID:D060050]
Myocardial Infarction[MeSHID:D009203]
Cerebrovascular Disorders[MeSHID:D002561]
Dyslipidemias[MeSHID:D050171]
Hypercholesterolemia[MeSHID:D006937]
Hypertriglyceridemia[MeSHID:D015228]
Prescription of drug (procedure)[MeSHID:D011307]
Hyperlipidemia[MeSHID:D006949]
Coronary heart disease[MeSHID:D003327]
Cerebrovascular accident[MeSHID:D020521]
Homozygote[MeSHID:D006720]
Heart[MeSHID:D006321]
Atherosclerosis[MeSHID:D050197]
Heterozygote[MeSHID:D006579]
Hypercholesterolemia
Familial[MeSHID:D006938]
Coronary Arteriosclerosis[MeSHID:D003324]
Disease[MeSHID:D004194]
Acute Coronary Syndrome[MeSHID:D054058]
Peripheral Arterial Diseases[MeSHID:D058729]
Hyperlipoproteinemia Type IV[MeSHID:D006953]
Hyperlipoproteinemia Type III[MeSHID:D006952]
Chronic Kidney Diseases[MeSHID:D051436]
Aortic Aneurysm
Abdominal[MeSHID:D017544]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]		 1.24 approved inhibitor
simvastatin hmg-coa reductase NA Successful target TTD , DGIDB Diabetes Mellitus[MeSHID:D003920]
Peripheral Vascular Diseases[MeSHID:D016491]
Cardiovascular Diseases[MeSHID:D002318]
Arteriosclerosis[MeSHID:D001161]
Stable angina[MeSHID:D060050]
Myocardial Infarction[MeSHID:D009203]
Cerebrovascular Disorders[MeSHID:D002561]
Dyslipidemias[MeSHID:D050171]
Hypercholesterolemia[MeSHID:D006937]
Hypertriglyceridemia[MeSHID:D015228]
Prescription of drug (procedure)[MeSHID:D011307]
Hyperlipidemia[MeSHID:D006949]
Coronary heart disease[MeSHID:D003327]
Cerebrovascular accident[MeSHID:D020521]
Homozygote[MeSHID:D006720]
Heart[MeSHID:D006321]
Atherosclerosis[MeSHID:D050197]
Heterozygote[MeSHID:D006579]
Hypercholesterolemia
Familial[MeSHID:D006938]
Coronary Arteriosclerosis[MeSHID:D003324]
Disease[MeSHID:D004194]
Acute Coronary Syndrome[MeSHID:D054058]
Peripheral Arterial Diseases[MeSHID:D058729]
Hyperlipoproteinemia Type IV[MeSHID:D006953]
Hyperlipoproteinemia Type III[MeSHID:D006952]
Chronic Kidney Diseases[MeSHID:D051436]
Aortic Aneurysm
Abdominal[MeSHID:D017544]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]		 1.24 approved inhibitor
simvastatin integrin alpha-l small molecule NA drugbank Diabetes Mellitus[MeSHID:D003920]
Peripheral Vascular Diseases[MeSHID:D016491]
Cardiovascular Diseases[MeSHID:D002318]
Arteriosclerosis[MeSHID:D001161]
Stable angina[MeSHID:D060050]
Myocardial Infarction[MeSHID:D009203]
Cerebrovascular Disorders[MeSHID:D002561]
Dyslipidemias[MeSHID:D050171]
Hypercholesterolemia[MeSHID:D006937]
Hypertriglyceridemia[MeSHID:D015228]
Prescription of drug (procedure)[MeSHID:D011307]
Hyperlipidemia[MeSHID:D006949]
Coronary heart disease[MeSHID:D003327]
Cerebrovascular accident[MeSHID:D020521]
Homozygote[MeSHID:D006720]
Heart[MeSHID:D006321]
Atherosclerosis[MeSHID:D050197]
Heterozygote[MeSHID:D006579]
Hypercholesterolemia
Familial[MeSHID:D006938]
Coronary Arteriosclerosis[MeSHID:D003324]
Disease[MeSHID:D004194]
Acute Coronary Syndrome[MeSHID:D054058]
Peripheral Arterial Diseases[MeSHID:D058729]
Hyperlipoproteinemia Type IV[MeSHID:D006953]
Hyperlipoproteinemia Type III[MeSHID:D006952]
Chronic Kidney Diseases[MeSHID:D051436]
Aortic Aneurysm
Abdominal[MeSHID:D017544]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]		 NA approved inhibitory allosteric modulator
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