| Drug-Target Information | ||||||||
|---|---|---|---|---|---|---|---|---|
| Drug Name | Target Name | Drug Type | Target Type | Source | Drug MeSHID | Interaction Score | Drug Status | Target Action |
| quetiapine | alpha-1 adrenergic receptors | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | antagonist |
| quetiapine | alpha-1 adrenergic receptors | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
0.08 | approved | antagonist |
| quetiapine | alpha-1 adrenergic receptors | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | antagonist |
| quetiapine | alpha-2a adrenergic receptor | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | antagonist |
| quetiapine | alpha-2b adrenergic receptor | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | antagonist |
| quetiapine | alpha-2c adrenergic receptor | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | antagonist |
| quetiapine | muscarinic acetylcholine receptor m1 | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | antagonist |
| quetiapine | muscarinic acetylcholine receptor m2 | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | ligand |
| quetiapine | muscarinic acetylcholine receptor m3 | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | antagonist |
| quetiapine | muscarinic acetylcholine receptor m4 | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | ligand |
| quetiapine | muscarinic acetylcholine receptor m5 | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | ligand |
| quetiapine | dopamine d1 receptor | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
0.05 | approved | antagonist |
| quetiapine | dopamine d2 receptor | small molecule | Successful target | TTD , drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
0.13 | approved | antagonist |
| quetiapine | dopamine d3 receptor | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
0.12 | approved | ligand |
| quetiapine | dopamine d4 receptor | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | ligand |
| quetiapine | dopamine d5 receptor | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | ligand |
| quetiapine | histamine h1 receptor | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
0.05 | approved | antagonist |
| quetiapine | 5-hydroxytryptamine receptor 1a | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
0.18 | approved | antagonist,partial agonist,agonist |
| quetiapine | 5-hydroxytryptamine receptor 1a | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
0.18 | approved | antagonist,partial agonist |
| quetiapine | 5-hydroxytryptamine receptor 1b | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | ligand |
| quetiapine | 5-hydroxytryptamine receptor 1d | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
0.1 | approved | ligand,agonist |
| quetiapine | 5-hydroxytryptamine receptor 1e | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
0.12 | approved | ligand,agonist |
| quetiapine | 5-hydroxytryptamine receptor 2a | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
0.11 | approved | antagonist,agonist |
| quetiapine | 5-hydroxytryptamine receptor 2a | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
0.11 | approved | antagonist |
| quetiapine | 5-hydroxytryptamine receptor 2c | small molecule | NA | drugbank , DGIDB | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
0.13 | approved | ligand |
| quetiapine | 5-hydroxytryptamine receptor 3a | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | ligand |
| quetiapine | 5-hydroxytryptamine receptor 6 | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | antagonist |
| quetiapine | 5-hydroxytryptamine receptor 7 | small molecule | NA | drugbank | Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Schizophrenia[MeSHID:D012559] Bipolar Disorder[MeSHID:D001714] Psychotic Disorders[MeSHID:D011618] Unipolar Depression[MeSHID:D003866] Disease[MeSHID:D004194] Post-Traumatic Stress Disorder[MeSHID:D013313] Parkinson Disease[MeSHID:D010300] Anxiety Disorders[MeSHID:D001008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Alcoholic Intoxication Chronic[MeSHID:D000437] |
NA | approved | ligand |
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