| Drug-Target Information | ||||||||
|---|---|---|---|---|---|---|---|---|
| Drug Name | Target Name | Drug Type | Target Type | Source | Drug MeSHID | Interaction Score | Drug Status | Target Action |
| nortriptyline | alpha-1a adrenergic receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | alpha-1b adrenergic receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | alpha-1d adrenergic receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | alpha-2 adrenergic receptors | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | alpha-2 adrenergic receptors | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | alpha-2 adrenergic receptors | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | beta adrenergic receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | beta adrenergic receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | beta adrenergic receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | muscarinic acetylcholine receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | muscarinic acetylcholine receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | muscarinic acetylcholine receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | muscarinic acetylcholine receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | muscarinic acetylcholine receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | dopamine d2 receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | histamine h1 receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | 5-hydroxytryptamine receptor 1a | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | 5-hydroxytryptamine receptor 2a | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist |
| nortriptyline | 5-hydroxytryptamine receptor 2c | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | antagonist,downregulator |
| nortriptyline | sigma receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | binder |
| nortriptyline | sigma receptor | small molecule | NA | drugbank | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
NA | approved | binder |
| nortriptyline | sodium-dependent noradrenaline transporter | small molecule | NA | drugbank , DGIDB | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
0.97 | approved | inhibitor |
| nortriptyline | serotonin transporter | NA | Successful target | TTD , DGIDB | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
0.81 | approved | unknown |
| nortriptyline | sodium-dependent serotonin transporter | small molecule | NA | drugbank , DGIDB | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
0.81 | approved | inhibitor |
| nortriptyline | serotonin transporter | NA | Successful target | TTD , DGIDB | Irritable Bowel Syndrome[MeSHID:D043183] Depressive Symptoms[MeSHID:D003863] Pain[MeSHID:D010146] Neuralgia[MeSHID:D009437] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] |
0.81 | approved | inhibitor |
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