| Drug-Target Information | ||||||||
|---|---|---|---|---|---|---|---|---|
| Drug Name | Target Name | Drug Type | Target Type | Source | Drug MeSHID | Interaction Score | Drug Status | Target Action |
| midostaurin | fms-like tyrosine kinase 3 | NA | Successful target | TTD , DGIDB | Mastocytosis Systemic[MeSHID:D034721] Leukemia Mast-Cell[MeSHID:D007946] Hematologic Neoplasms[MeSHID:D019337] Myelocytic Acute[MeSHID:D015470] Mutation[MeSHID:D009154] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Myelomonocytic Chronic[MeSHID:D015477] Colorectal Cancer[MeSHID:D015179] |
1.27 | approved | unknown |
| midostaurin | receptor-type tyrosine-protein kinase flt3 | small molecule | NA | drugbank , DGIDB | Mastocytosis Systemic[MeSHID:D034721] Leukemia Mast-Cell[MeSHID:D007946] Hematologic Neoplasms[MeSHID:D019337] Myelocytic Acute[MeSHID:D015470] Mutation[MeSHID:D009154] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Myelomonocytic Chronic[MeSHID:D015477] Colorectal Cancer[MeSHID:D015179] |
1.27 | approved,investigational | antagonist,inhibitor |
| midostaurin | fms-like tyrosine kinase 3 | NA | Successful target | TTD , DGIDB | Mastocytosis Systemic[MeSHID:D034721] Leukemia Mast-Cell[MeSHID:D007946] Hematologic Neoplasms[MeSHID:D019337] Myelocytic Acute[MeSHID:D015470] Mutation[MeSHID:D009154] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Myelomonocytic Chronic[MeSHID:D015477] Colorectal Cancer[MeSHID:D015179] |
1.27 | approved | inhibitor |
| midostaurin | vascular endothelial growth factor receptor 2 | small molecule | NA | drugbank , DGIDB | Mastocytosis Systemic[MeSHID:D034721] Leukemia Mast-Cell[MeSHID:D007946] Hematologic Neoplasms[MeSHID:D019337] Myelocytic Acute[MeSHID:D015470] Mutation[MeSHID:D009154] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Myelomonocytic Chronic[MeSHID:D015477] Colorectal Cancer[MeSHID:D015179] |
0.06 | approved,investigational | antagonist,inhibitor |
| midostaurin | mast/stem cell growth factor receptor kit | small molecule | NA | drugbank , DGIDB | Mastocytosis Systemic[MeSHID:D034721] Leukemia Mast-Cell[MeSHID:D007946] Hematologic Neoplasms[MeSHID:D019337] Myelocytic Acute[MeSHID:D015470] Mutation[MeSHID:D009154] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Myelomonocytic Chronic[MeSHID:D015477] Colorectal Cancer[MeSHID:D015179] |
0.32 | approved,investigational | antagonist,inhibitor |
| midostaurin | platelet-derived growth factor receptor alpha | small molecule | NA | drugbank , DGIDB | Mastocytosis Systemic[MeSHID:D034721] Leukemia Mast-Cell[MeSHID:D007946] Hematologic Neoplasms[MeSHID:D019337] Myelocytic Acute[MeSHID:D015470] Mutation[MeSHID:D009154] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Myelomonocytic Chronic[MeSHID:D015477] Colorectal Cancer[MeSHID:D015179] |
0.12 | approved,investigational | antagonist,inhibitor |
| midostaurin | platelet-derived growth factor receptor beta | small molecule | NA | drugbank , DGIDB | Mastocytosis Systemic[MeSHID:D034721] Leukemia Mast-Cell[MeSHID:D007946] Hematologic Neoplasms[MeSHID:D019337] Myelocytic Acute[MeSHID:D015470] Mutation[MeSHID:D009154] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Myelomonocytic Chronic[MeSHID:D015477] Colorectal Cancer[MeSHID:D015179] |
0.06 | approved,investigational | antagonist,inhibitor |
| midostaurin | protein kinase c alpha type | small molecule | NA | drugbank , DGIDB | Mastocytosis Systemic[MeSHID:D034721] Leukemia Mast-Cell[MeSHID:D007946] Hematologic Neoplasms[MeSHID:D019337] Myelocytic Acute[MeSHID:D015470] Mutation[MeSHID:D009154] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Myelomonocytic Chronic[MeSHID:D015477] Colorectal Cancer[MeSHID:D015179] |
0.35 | approved,investigational | antagonist,inhibitor |
| midostaurin | protein kinase c gamma | NA | Successful target | TTD , DGIDB | Mastocytosis Systemic[MeSHID:D034721] Leukemia Mast-Cell[MeSHID:D007946] Hematologic Neoplasms[MeSHID:D019337] Myelocytic Acute[MeSHID:D015470] Mutation[MeSHID:D009154] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Myelomonocytic Chronic[MeSHID:D015477] Colorectal Cancer[MeSHID:D015179] |
0.21 | approved | inhibitor |
| midostaurin | protein kinase c gamma | NA | Successful target | TTD , DGIDB | Mastocytosis Systemic[MeSHID:D034721] Leukemia Mast-Cell[MeSHID:D007946] Hematologic Neoplasms[MeSHID:D019337] Myelocytic Acute[MeSHID:D015470] Mutation[MeSHID:D009154] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Myelomonocytic Chronic[MeSHID:D015477] Colorectal Cancer[MeSHID:D015179] |
0.21 | approved | unknown |
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