Drug-Target Information
Drug Name Target Name Drug Type Target Type Source Drug MeSHID Interaction Score Drug Status Target Action
methotrexate bifunctional purine biosynthesis protein purh small molecule NA drugbank , DGIDB Solutions[MeSHID:D012996]
Neoplasms[MeSHID:D009369]
Maintenance[MeSHID:D008283]
Mycosis Fungoides[MeSHID:D009182]
Operative Surgical Procedures[MeSHID:D013514]
Rheumatoid Arthritis[MeSHID:D001172]
Cancer of Head[MeSHID:D006258]
Pregnancy[MeSHID:D011247]
Malignant neoplasm of lung[MeSHID:D008175]
Nevus[MeSHID:D009506]
Choriocarcinoma[MeSHID:D002822]
Osteosarcoma[MeSHID:D012516]
Leukemia
Lymphocytic
Acute
L1[MeSHID:D054198]
Malignant neoplasm of breast[MeSHID:D001943]
Continuance of life[MeSHID:D013534]
Hydatidiform Mole
Invasive[MeSHID:D002820]
Juvenile arthritis[MeSHID:D001171]
Lymphoma
Non-Hodgkin[MeSHID:D008228]
Psoriasis[MeSHID:D011565]
Relapse[MeSHID:D012008]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Coronavirus Infections[MeSHID:D018352]
Disease[MeSHID:D004194]		 4.13 approved inhibitor
methotrexate bifunctional purine biosynthesis protein purh small molecule NA drugbank , DGIDB Solutions[MeSHID:D012996]
Neoplasms[MeSHID:D009369]
Maintenance[MeSHID:D008283]
Mycosis Fungoides[MeSHID:D009182]
Operative Surgical Procedures[MeSHID:D013514]
Rheumatoid Arthritis[MeSHID:D001172]
Cancer of Head[MeSHID:D006258]
Pregnancy[MeSHID:D011247]
Malignant neoplasm of lung[MeSHID:D008175]
Nevus[MeSHID:D009506]
Choriocarcinoma[MeSHID:D002822]
Osteosarcoma[MeSHID:D012516]
Leukemia
Lymphocytic
Acute
L1[MeSHID:D054198]
Malignant neoplasm of breast[MeSHID:D001943]
Continuance of life[MeSHID:D013534]
Hydatidiform Mole
Invasive[MeSHID:D002820]
Juvenile arthritis[MeSHID:D001171]
Lymphoma
Non-Hodgkin[MeSHID:D008228]
Psoriasis[MeSHID:D011565]
Relapse[MeSHID:D012008]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Proliferative vitreoretinopathy[MeSHID:D018630]
leukemia[MeSHID:D007938]
Malignant neoplasm of prostate[MeSHID:D011471]
Malignant Neoplasms[MeSHID:D009369]		 4.13 approved inhibitor
methotrexate dihydrofolate reductase small molecule NA drugbank , DGIDB Solutions[MeSHID:D012996]
Neoplasms[MeSHID:D009369]
Maintenance[MeSHID:D008283]
Mycosis Fungoides[MeSHID:D009182]
Operative Surgical Procedures[MeSHID:D013514]
Rheumatoid Arthritis[MeSHID:D001172]
Cancer of Head[MeSHID:D006258]
Pregnancy[MeSHID:D011247]
Malignant neoplasm of lung[MeSHID:D008175]
Nevus[MeSHID:D009506]
Choriocarcinoma[MeSHID:D002822]
Osteosarcoma[MeSHID:D012516]
Leukemia
Lymphocytic
Acute
L1[MeSHID:D054198]
Malignant neoplasm of breast[MeSHID:D001943]
Continuance of life[MeSHID:D013534]
Hydatidiform Mole
Invasive[MeSHID:D002820]
Juvenile arthritis[MeSHID:D001171]
Lymphoma
Non-Hodgkin[MeSHID:D008228]
Psoriasis[MeSHID:D011565]
Relapse[MeSHID:D012008]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Coronavirus Infections[MeSHID:D018352]
Disease[MeSHID:D004194]		 1.03 approved inhibitor
methotrexate dihydrofolate reductase small molecule NA drugbank , DGIDB Solutions[MeSHID:D012996]
Neoplasms[MeSHID:D009369]
Maintenance[MeSHID:D008283]
Mycosis Fungoides[MeSHID:D009182]
Operative Surgical Procedures[MeSHID:D013514]
Rheumatoid Arthritis[MeSHID:D001172]
Cancer of Head[MeSHID:D006258]
Pregnancy[MeSHID:D011247]
Malignant neoplasm of lung[MeSHID:D008175]
Nevus[MeSHID:D009506]
Choriocarcinoma[MeSHID:D002822]
Osteosarcoma[MeSHID:D012516]
Leukemia
Lymphocytic
Acute
L1[MeSHID:D054198]
Malignant neoplasm of breast[MeSHID:D001943]
Continuance of life[MeSHID:D013534]
Hydatidiform Mole
Invasive[MeSHID:D002820]
Juvenile arthritis[MeSHID:D001171]
Lymphoma
Non-Hodgkin[MeSHID:D008228]
Psoriasis[MeSHID:D011565]
Relapse[MeSHID:D012008]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Proliferative vitreoretinopathy[MeSHID:D018630]
leukemia[MeSHID:D007938]
Malignant neoplasm of prostate[MeSHID:D011471]
Malignant Neoplasms[MeSHID:D009369]		 1.03 approved inhibitor
methotrexate solute carrier family 19 member 1 NA Successful target TTD , DGIDB Solutions[MeSHID:D012996]
Neoplasms[MeSHID:D009369]
Maintenance[MeSHID:D008283]
Mycosis Fungoides[MeSHID:D009182]
Operative Surgical Procedures[MeSHID:D013514]
Rheumatoid Arthritis[MeSHID:D001172]
Cancer of Head[MeSHID:D006258]
Pregnancy[MeSHID:D011247]
Malignant neoplasm of lung[MeSHID:D008175]
Nevus[MeSHID:D009506]
Choriocarcinoma[MeSHID:D002822]
Osteosarcoma[MeSHID:D012516]
Leukemia
Lymphocytic
Acute
L1[MeSHID:D054198]
Malignant neoplasm of breast[MeSHID:D001943]
Continuance of life[MeSHID:D013534]
Hydatidiform Mole
Invasive[MeSHID:D002820]
Juvenile arthritis[MeSHID:D001171]
Lymphoma
Non-Hodgkin[MeSHID:D008228]
Psoriasis[MeSHID:D011565]
Relapse[MeSHID:D012008]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Proliferative vitreoretinopathy[MeSHID:D018630]
leukemia[MeSHID:D007938]
Malignant neoplasm of prostate[MeSHID:D011471]
Malignant Neoplasms[MeSHID:D009369]		 0.11 approved inhibitor
methotrexate solute carrier family 19 member 1 NA Successful target TTD , DGIDB Solutions[MeSHID:D012996]
Neoplasms[MeSHID:D009369]
Maintenance[MeSHID:D008283]
Mycosis Fungoides[MeSHID:D009182]
Operative Surgical Procedures[MeSHID:D013514]
Rheumatoid Arthritis[MeSHID:D001172]
Cancer of Head[MeSHID:D006258]
Pregnancy[MeSHID:D011247]
Malignant neoplasm of lung[MeSHID:D008175]
Nevus[MeSHID:D009506]
Choriocarcinoma[MeSHID:D002822]
Osteosarcoma[MeSHID:D012516]
Leukemia
Lymphocytic
Acute
L1[MeSHID:D054198]
Malignant neoplasm of breast[MeSHID:D001943]
Continuance of life[MeSHID:D013534]
Hydatidiform Mole
Invasive[MeSHID:D002820]
Juvenile arthritis[MeSHID:D001171]
Lymphoma
Non-Hodgkin[MeSHID:D008228]
Psoriasis[MeSHID:D011565]
Relapse[MeSHID:D012008]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Coronavirus Infections[MeSHID:D018352]
Disease[MeSHID:D004194]		 0.11 approved inhibitor
methotrexate solute carrier family 19 member 1 NA Successful target TTD , DGIDB Solutions[MeSHID:D012996]
Neoplasms[MeSHID:D009369]
Maintenance[MeSHID:D008283]
Mycosis Fungoides[MeSHID:D009182]
Operative Surgical Procedures[MeSHID:D013514]
Rheumatoid Arthritis[MeSHID:D001172]
Cancer of Head[MeSHID:D006258]
Pregnancy[MeSHID:D011247]
Malignant neoplasm of lung[MeSHID:D008175]
Nevus[MeSHID:D009506]
Choriocarcinoma[MeSHID:D002822]
Osteosarcoma[MeSHID:D012516]
Leukemia
Lymphocytic
Acute
L1[MeSHID:D054198]
Malignant neoplasm of breast[MeSHID:D001943]
Continuance of life[MeSHID:D013534]
Hydatidiform Mole
Invasive[MeSHID:D002820]
Juvenile arthritis[MeSHID:D001171]
Lymphoma
Non-Hodgkin[MeSHID:D008228]
Psoriasis[MeSHID:D011565]
Relapse[MeSHID:D012008]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Coronavirus Infections[MeSHID:D018352]
Disease[MeSHID:D004194]		 0.11 approved unknown
methotrexate solute carrier family 19 member 1 NA Successful target TTD , DGIDB Solutions[MeSHID:D012996]
Neoplasms[MeSHID:D009369]
Maintenance[MeSHID:D008283]
Mycosis Fungoides[MeSHID:D009182]
Operative Surgical Procedures[MeSHID:D013514]
Rheumatoid Arthritis[MeSHID:D001172]
Cancer of Head[MeSHID:D006258]
Pregnancy[MeSHID:D011247]
Malignant neoplasm of lung[MeSHID:D008175]
Nevus[MeSHID:D009506]
Choriocarcinoma[MeSHID:D002822]
Osteosarcoma[MeSHID:D012516]
Leukemia
Lymphocytic
Acute
L1[MeSHID:D054198]
Malignant neoplasm of breast[MeSHID:D001943]
Continuance of life[MeSHID:D013534]
Hydatidiform Mole
Invasive[MeSHID:D002820]
Juvenile arthritis[MeSHID:D001171]
Lymphoma
Non-Hodgkin[MeSHID:D008228]
Psoriasis[MeSHID:D011565]
Relapse[MeSHID:D012008]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Proliferative vitreoretinopathy[MeSHID:D018630]
leukemia[MeSHID:D007938]
Malignant neoplasm of prostate[MeSHID:D011471]
Malignant Neoplasms[MeSHID:D009369]		 0.11 approved unknown
methotrexate proton-coupled folate transporter NA Successful target TTD , DGIDB Solutions[MeSHID:D012996]
Neoplasms[MeSHID:D009369]
Maintenance[MeSHID:D008283]
Mycosis Fungoides[MeSHID:D009182]
Operative Surgical Procedures[MeSHID:D013514]
Rheumatoid Arthritis[MeSHID:D001172]
Cancer of Head[MeSHID:D006258]
Pregnancy[MeSHID:D011247]
Malignant neoplasm of lung[MeSHID:D008175]
Nevus[MeSHID:D009506]
Choriocarcinoma[MeSHID:D002822]
Osteosarcoma[MeSHID:D012516]
Leukemia
Lymphocytic
Acute
L1[MeSHID:D054198]
Malignant neoplasm of breast[MeSHID:D001943]
Continuance of life[MeSHID:D013534]
Hydatidiform Mole
Invasive[MeSHID:D002820]
Juvenile arthritis[MeSHID:D001171]
Lymphoma
Non-Hodgkin[MeSHID:D008228]
Psoriasis[MeSHID:D011565]
Relapse[MeSHID:D012008]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Coronavirus Infections[MeSHID:D018352]
Disease[MeSHID:D004194]		 0.44 approved unknown
methotrexate proton-coupled folate transporter NA Successful target TTD , DGIDB Solutions[MeSHID:D012996]
Neoplasms[MeSHID:D009369]
Maintenance[MeSHID:D008283]
Mycosis Fungoides[MeSHID:D009182]
Operative Surgical Procedures[MeSHID:D013514]
Rheumatoid Arthritis[MeSHID:D001172]
Cancer of Head[MeSHID:D006258]
Pregnancy[MeSHID:D011247]
Malignant neoplasm of lung[MeSHID:D008175]
Nevus[MeSHID:D009506]
Choriocarcinoma[MeSHID:D002822]
Osteosarcoma[MeSHID:D012516]
Leukemia
Lymphocytic
Acute
L1[MeSHID:D054198]
Malignant neoplasm of breast[MeSHID:D001943]
Continuance of life[MeSHID:D013534]
Hydatidiform Mole
Invasive[MeSHID:D002820]
Juvenile arthritis[MeSHID:D001171]
Lymphoma
Non-Hodgkin[MeSHID:D008228]
Psoriasis[MeSHID:D011565]
Relapse[MeSHID:D012008]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Proliferative vitreoretinopathy[MeSHID:D018630]
leukemia[MeSHID:D007938]
Malignant neoplasm of prostate[MeSHID:D011471]
Malignant Neoplasms[MeSHID:D009369]		 0.44 approved unknown
methotrexate thymidylate synthase small molecule NA drugbank , DGIDB Solutions[MeSHID:D012996]
Neoplasms[MeSHID:D009369]
Maintenance[MeSHID:D008283]
Mycosis Fungoides[MeSHID:D009182]
Operative Surgical Procedures[MeSHID:D013514]
Rheumatoid Arthritis[MeSHID:D001172]
Cancer of Head[MeSHID:D006258]
Pregnancy[MeSHID:D011247]
Malignant neoplasm of lung[MeSHID:D008175]
Nevus[MeSHID:D009506]
Choriocarcinoma[MeSHID:D002822]
Osteosarcoma[MeSHID:D012516]
Leukemia
Lymphocytic
Acute
L1[MeSHID:D054198]
Malignant neoplasm of breast[MeSHID:D001943]
Continuance of life[MeSHID:D013534]
Hydatidiform Mole
Invasive[MeSHID:D002820]
Juvenile arthritis[MeSHID:D001171]
Lymphoma
Non-Hodgkin[MeSHID:D008228]
Psoriasis[MeSHID:D011565]
Relapse[MeSHID:D012008]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Coronavirus Infections[MeSHID:D018352]
Disease[MeSHID:D004194]		 0.05 approved inhibitor
methotrexate thymidylate synthase small molecule NA drugbank , DGIDB Solutions[MeSHID:D012996]
Neoplasms[MeSHID:D009369]
Maintenance[MeSHID:D008283]
Mycosis Fungoides[MeSHID:D009182]
Operative Surgical Procedures[MeSHID:D013514]
Rheumatoid Arthritis[MeSHID:D001172]
Cancer of Head[MeSHID:D006258]
Pregnancy[MeSHID:D011247]
Malignant neoplasm of lung[MeSHID:D008175]
Nevus[MeSHID:D009506]
Choriocarcinoma[MeSHID:D002822]
Osteosarcoma[MeSHID:D012516]
Leukemia
Lymphocytic
Acute
L1[MeSHID:D054198]
Malignant neoplasm of breast[MeSHID:D001943]
Continuance of life[MeSHID:D013534]
Hydatidiform Mole
Invasive[MeSHID:D002820]
Juvenile arthritis[MeSHID:D001171]
Lymphoma
Non-Hodgkin[MeSHID:D008228]
Psoriasis[MeSHID:D011565]
Relapse[MeSHID:D012008]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Proliferative vitreoretinopathy[MeSHID:D018630]
leukemia[MeSHID:D007938]
Malignant neoplasm of prostate[MeSHID:D011471]
Malignant Neoplasms[MeSHID:D009369]		 0.05 approved inhibitor
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