| Drug-Target Information | ||||||||
|---|---|---|---|---|---|---|---|---|
| Drug Name | Target Name | Drug Type | Target Type | Source | Drug MeSHID | Interaction Score | Drug Status | Target Action |
| maprotiline | alpha-1 adrenergic receptors | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | antagonist |
| maprotiline | alpha-1 adrenergic receptors | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | antagonist |
| maprotiline | alpha-1 adrenergic receptors | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | antagonist |
| maprotiline | alpha-2 adrenergic receptors | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | antagonist |
| maprotiline | alpha-2 adrenergic receptors | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | antagonist |
| maprotiline | alpha-2 adrenergic receptors | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | antagonist |
| maprotiline | muscarinic acetylcholine receptor m1 | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | antagonist |
| maprotiline | muscarinic acetylcholine receptor m2 | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | antagonist |
| maprotiline | muscarinic acetylcholine receptor m3 | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | antagonist |
| maprotiline | muscarinic acetylcholine receptor m4 | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | antagonist |
| maprotiline | muscarinic acetylcholine receptor m5 | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | antagonist |
| maprotiline | dopamine d2 receptor | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | binder |
| maprotiline | histamine h1 receptor | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | antagonist |
| maprotiline | 5-hydroxytryptamine receptor 2a | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | binder |
| maprotiline | 5-hydroxytryptamine receptor 2c | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | binder |
| maprotiline | 5-hydroxytryptamine receptor 7 | small molecule | NA | drugbank | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
NA | approved,investigational | antagonist |
| maprotiline | norepinephrine transporter | NA | Successful target | TTD , DGIDB | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
0.87 | approved | unknown |
| maprotiline | sodium-dependent noradrenaline transporter | small molecule | NA | drugbank , DGIDB | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
0.87 | approved,investigational | inhibitor |
| maprotiline | norepinephrine transporter | NA | Successful target | TTD , DGIDB | Involutional Depression[MeSHID:D003865] Mental Suffering[MeSHID:D013315] Mental Depression[MeSHID:D003863] Depressive disorder[MeSHID:D003866] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Major Depressive Disorder[MeSHID:D003865] Unipolar Depression[MeSHID:D003866] |
0.87 | approved | inhibitor |
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