| Drug-Target Information | ||||||||
|---|---|---|---|---|---|---|---|---|
| Drug Name | Target Name | Drug Type | Target Type | Source | Drug MeSHID | Interaction Score | Drug Status | Target Action |
| lofexidine | alpha-1a adrenergic receptor | small molecule | NA | drugbank | Disease Management[MeSHID:D019468] Abdominal Pain[MeSHID:D015746] Opiate Addiction[MeSHID:D009293] Disease[MeSHID:D004194] Nausea[MeSHID:D009325] Diarrhea[MeSHID:D003967] Mydriasis[MeSHID:D015878] Piloerection[MeSHID:D010863] Substance Withdrawal Syndrome[MeSHID:D013375] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational | agonist |
| lofexidine | alpha-2a adrenergic receptor | small molecule | NA | drugbank , DGIDB | Disease Management[MeSHID:D019468] Abdominal Pain[MeSHID:D015746] Opiate Addiction[MeSHID:D009293] Disease[MeSHID:D004194] Nausea[MeSHID:D009325] Diarrhea[MeSHID:D003967] Mydriasis[MeSHID:D015878] Piloerection[MeSHID:D010863] Substance Withdrawal Syndrome[MeSHID:D013375] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
1.3 | approved,investigational | agonist |
| lofexidine | adrenergic receptor alpha-2a | NA | Successful target | TTD , DGIDB | Disease Management[MeSHID:D019468] Abdominal Pain[MeSHID:D015746] Opiate Addiction[MeSHID:D009293] Disease[MeSHID:D004194] Nausea[MeSHID:D009325] Diarrhea[MeSHID:D003967] Mydriasis[MeSHID:D015878] Piloerection[MeSHID:D010863] Substance Withdrawal Syndrome[MeSHID:D013375] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
1.3 | approved | agonist |
| lofexidine | adrenergic receptor alpha-2a | NA | Successful target | TTD , DGIDB | Disease Management[MeSHID:D019468] Abdominal Pain[MeSHID:D015746] Opiate Addiction[MeSHID:D009293] Disease[MeSHID:D004194] Nausea[MeSHID:D009325] Diarrhea[MeSHID:D003967] Mydriasis[MeSHID:D015878] Piloerection[MeSHID:D010863] Substance Withdrawal Syndrome[MeSHID:D013375] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
1.3 | approved | unknown |
| lofexidine | 5-hydroxytryptamine receptor 1a | small molecule | NA | drugbank | Disease Management[MeSHID:D019468] Abdominal Pain[MeSHID:D015746] Opiate Addiction[MeSHID:D009293] Disease[MeSHID:D004194] Nausea[MeSHID:D009325] Diarrhea[MeSHID:D003967] Mydriasis[MeSHID:D015878] Piloerection[MeSHID:D010863] Substance Withdrawal Syndrome[MeSHID:D013375] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational | agonist |
| lofexidine | 5-hydroxytryptamine receptor 1d | small molecule | NA | drugbank | Disease Management[MeSHID:D019468] Abdominal Pain[MeSHID:D015746] Opiate Addiction[MeSHID:D009293] Disease[MeSHID:D004194] Nausea[MeSHID:D009325] Diarrhea[MeSHID:D003967] Mydriasis[MeSHID:D015878] Piloerection[MeSHID:D010863] Substance Withdrawal Syndrome[MeSHID:D013375] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational | agonist |
| lofexidine | 5-hydroxytryptamine receptor 2c | small molecule | NA | drugbank | Disease Management[MeSHID:D019468] Abdominal Pain[MeSHID:D015746] Opiate Addiction[MeSHID:D009293] Disease[MeSHID:D004194] Nausea[MeSHID:D009325] Diarrhea[MeSHID:D003967] Mydriasis[MeSHID:D015878] Piloerection[MeSHID:D010863] Substance Withdrawal Syndrome[MeSHID:D013375] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational | agonist |
| lofexidine | 5-hydroxytryptamine receptor 7 | small molecule | NA | drugbank | Disease Management[MeSHID:D019468] Abdominal Pain[MeSHID:D015746] Opiate Addiction[MeSHID:D009293] Disease[MeSHID:D004194] Nausea[MeSHID:D009325] Diarrhea[MeSHID:D003967] Mydriasis[MeSHID:D015878] Piloerection[MeSHID:D010863] Substance Withdrawal Syndrome[MeSHID:D013375] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational | agonist |
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