| Drug-Target Information | ||||||||
|---|---|---|---|---|---|---|---|---|
| Drug Name | Target Name | Drug Type | Target Type | Source | Drug MeSHID | Interaction Score | Drug Status | Target Action |
| gemcitabine | ump-cmp kinase | small molecule | NA | drugbank , DGIDB | Pancreas[MeSHID:D010179] Adenocarcinoma[MeSHID:D000230] Urinary Bladder[MeSHID:D001743] Malignant neoplasm of ovary[MeSHID:D010051] Malignant neoplasm of breast[MeSHID:D001943] Non-Small Cell Lung Carcinoma[MeSHID:D002289] Carcinoma Transitional Cell[MeSHID:D002295] Relapse[MeSHID:D012008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Malignant Neoplasms[MeSHID:D009369] |
2.36 | approved | inhibitor |
| gemcitabine | ump-cmp kinase | small molecule | NA | drugbank , DGIDB | Pancreas[MeSHID:D010179] Adenocarcinoma[MeSHID:D000230] Urinary Bladder[MeSHID:D001743] Malignant neoplasm of ovary[MeSHID:D010051] Malignant neoplasm of breast[MeSHID:D001943] Non-Small Cell Lung Carcinoma[MeSHID:D002289] Carcinoma Transitional Cell[MeSHID:D002295] Relapse[MeSHID:D012008] Severe Acute Respiratory Syndrome[MeSHID:D045169] Middle East Respiratory Syndrome[MeSHID:D018352] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
2.36 | approved | inhibitor |
| gemcitabine | ribonucleoside-diphosphate reductase large subunit | small molecule | NA | drugbank , DGIDB | Pancreas[MeSHID:D010179] Adenocarcinoma[MeSHID:D000230] Urinary Bladder[MeSHID:D001743] Malignant neoplasm of ovary[MeSHID:D010051] Malignant neoplasm of breast[MeSHID:D001943] Non-Small Cell Lung Carcinoma[MeSHID:D002289] Carcinoma Transitional Cell[MeSHID:D002295] Relapse[MeSHID:D012008] Severe Acute Respiratory Syndrome[MeSHID:D045169] Middle East Respiratory Syndrome[MeSHID:D018352] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
1.07 | approved | inhibitor |
| gemcitabine | ribonucleoside-diphosphate reductase large subunit | small molecule | NA | drugbank , DGIDB | Pancreas[MeSHID:D010179] Adenocarcinoma[MeSHID:D000230] Urinary Bladder[MeSHID:D001743] Malignant neoplasm of ovary[MeSHID:D010051] Malignant neoplasm of breast[MeSHID:D001943] Non-Small Cell Lung Carcinoma[MeSHID:D002289] Carcinoma Transitional Cell[MeSHID:D002295] Relapse[MeSHID:D012008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Malignant Neoplasms[MeSHID:D009369] |
1.07 | approved | inhibitor |
| gemcitabine | ribonucleoside-diphosphate reductase m2 | NA | Successful target | TTD , DGIDB | Pancreas[MeSHID:D010179] Adenocarcinoma[MeSHID:D000230] Urinary Bladder[MeSHID:D001743] Malignant neoplasm of ovary[MeSHID:D010051] Malignant neoplasm of breast[MeSHID:D001943] Non-Small Cell Lung Carcinoma[MeSHID:D002289] Carcinoma Transitional Cell[MeSHID:D002295] Relapse[MeSHID:D012008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Malignant Neoplasms[MeSHID:D009369] |
0.18 | approved | inhibitor |
| gemcitabine | ribonucleoside-diphosphate reductase m2 | NA | Successful target | TTD , DGIDB | Pancreas[MeSHID:D010179] Adenocarcinoma[MeSHID:D000230] Urinary Bladder[MeSHID:D001743] Malignant neoplasm of ovary[MeSHID:D010051] Malignant neoplasm of breast[MeSHID:D001943] Non-Small Cell Lung Carcinoma[MeSHID:D002289] Carcinoma Transitional Cell[MeSHID:D002295] Relapse[MeSHID:D012008] Severe Acute Respiratory Syndrome[MeSHID:D045169] Middle East Respiratory Syndrome[MeSHID:D018352] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
0.18 | approved | inhibitor |
| gemcitabine | ribonucleoside-diphosphate reductase m2 | NA | Successful target | TTD , DGIDB | Pancreas[MeSHID:D010179] Adenocarcinoma[MeSHID:D000230] Urinary Bladder[MeSHID:D001743] Malignant neoplasm of ovary[MeSHID:D010051] Malignant neoplasm of breast[MeSHID:D001943] Non-Small Cell Lung Carcinoma[MeSHID:D002289] Carcinoma Transitional Cell[MeSHID:D002295] Relapse[MeSHID:D012008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Malignant Neoplasms[MeSHID:D009369] |
0.18 | approved | unknown |
| gemcitabine | ribonucleoside-diphosphate reductase m2 | NA | Successful target | TTD , DGIDB | Pancreas[MeSHID:D010179] Adenocarcinoma[MeSHID:D000230] Urinary Bladder[MeSHID:D001743] Malignant neoplasm of ovary[MeSHID:D010051] Malignant neoplasm of breast[MeSHID:D001943] Non-Small Cell Lung Carcinoma[MeSHID:D002289] Carcinoma Transitional Cell[MeSHID:D002295] Relapse[MeSHID:D012008] Severe Acute Respiratory Syndrome[MeSHID:D045169] Middle East Respiratory Syndrome[MeSHID:D018352] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
0.18 | approved | unknown |
| gemcitabine | thymidylate synthase | small molecule | NA | drugbank | Pancreas[MeSHID:D010179] Adenocarcinoma[MeSHID:D000230] Urinary Bladder[MeSHID:D001743] Malignant neoplasm of ovary[MeSHID:D010051] Malignant neoplasm of breast[MeSHID:D001943] Non-Small Cell Lung Carcinoma[MeSHID:D002289] Carcinoma Transitional Cell[MeSHID:D002295] Relapse[MeSHID:D012008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Malignant Neoplasms[MeSHID:D009369] |
NA | approved | inhibitor |
| gemcitabine | thymidylate synthase | small molecule | NA | drugbank | Pancreas[MeSHID:D010179] Adenocarcinoma[MeSHID:D000230] Urinary Bladder[MeSHID:D001743] Malignant neoplasm of ovary[MeSHID:D010051] Malignant neoplasm of breast[MeSHID:D001943] Non-Small Cell Lung Carcinoma[MeSHID:D002289] Carcinoma Transitional Cell[MeSHID:D002295] Relapse[MeSHID:D012008] Severe Acute Respiratory Syndrome[MeSHID:D045169] Middle East Respiratory Syndrome[MeSHID:D018352] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved | inhibitor |
| gemcitabine | dna | small molecule | NA | drugbank | Pancreas[MeSHID:D010179] Adenocarcinoma[MeSHID:D000230] Urinary Bladder[MeSHID:D001743] Malignant neoplasm of ovary[MeSHID:D010051] Malignant neoplasm of breast[MeSHID:D001943] Non-Small Cell Lung Carcinoma[MeSHID:D002289] Carcinoma Transitional Cell[MeSHID:D002295] Relapse[MeSHID:D012008] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] Malignant Neoplasms[MeSHID:D009369] |
NA | approved | cross-linking/alkylation |
| gemcitabine | dna | small molecule | NA | drugbank | Pancreas[MeSHID:D010179] Adenocarcinoma[MeSHID:D000230] Urinary Bladder[MeSHID:D001743] Malignant neoplasm of ovary[MeSHID:D010051] Malignant neoplasm of breast[MeSHID:D001943] Non-Small Cell Lung Carcinoma[MeSHID:D002289] Carcinoma Transitional Cell[MeSHID:D002295] Relapse[MeSHID:D012008] Severe Acute Respiratory Syndrome[MeSHID:D045169] Middle East Respiratory Syndrome[MeSHID:D018352] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved | cross-linking/alkylation |
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