Drug-Target Information
Drug Name Target Name Drug Type Target Type Source Drug MeSHID Interaction Score Drug Status Target Action
epinephrine alpha-1a adrenergic receptor small molecule NA drugbank , DGIDB Structure of carotid sinus[MeSHID:D002346]
Operative Surgical Procedures[MeSHID:D013514]
Genetic Selection[MeSHID:D012641]
Heart Block[MeSHID:D006327]
Hypersensitivity[MeSHID:D006967]
Cardiac Arrest[MeSHID:D006323]
Angioedema[MeSHID:D000799]
Mucous Membrane[MeSHID:D009092]
Bronchi[MeSHID:D001980]
Shock
Cardiogenic[MeSHID:D012770]
Wheezing[MeSHID:D012135]
Uterine Contraction[MeSHID:D014590]
Rhinitis[MeSHID:D012220]
Urticaria[MeSHID:D014581]
Syncope[MeSHID:D013575]
Dyspnea[MeSHID:D004417]
anaphylaxis[MeSHID:D000707]
Sinusitis[MeSHID:D012852]
Relaxation[MeSHID:D012063]
Insect Bites[MeSHID:D007299]
Maintenance[MeSHID:D008283]
Glaucoma
Open-Angle[MeSHID:D005902]
Body Weight[MeSHID:D001835]
Heart failure[MeSHID:D006333]
Heart[MeSHID:D006321]
Asthma[MeSHID:D001249]
Accidents[MeSHID:D000059]
Hay fever[MeSHID:D006255]
Mydriasis[MeSHID:D015878]
myometrium[MeSHID:D009215]
Fire - disasters[MeSHID:D005390]
Hemorrhage[MeSHID:D006470]
Serum Sickness[MeSHID:D012713]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Allergic Reaction[MeSHID:D006967]		 0.16 approved,vet_approved agonist
epinephrine alpha-1b adrenergic receptor small molecule NA drugbank , DGIDB Structure of carotid sinus[MeSHID:D002346]
Operative Surgical Procedures[MeSHID:D013514]
Genetic Selection[MeSHID:D012641]
Heart Block[MeSHID:D006327]
Hypersensitivity[MeSHID:D006967]
Cardiac Arrest[MeSHID:D006323]
Angioedema[MeSHID:D000799]
Mucous Membrane[MeSHID:D009092]
Bronchi[MeSHID:D001980]
Shock
Cardiogenic[MeSHID:D012770]
Wheezing[MeSHID:D012135]
Uterine Contraction[MeSHID:D014590]
Rhinitis[MeSHID:D012220]
Urticaria[MeSHID:D014581]
Syncope[MeSHID:D013575]
Dyspnea[MeSHID:D004417]
anaphylaxis[MeSHID:D000707]
Sinusitis[MeSHID:D012852]
Relaxation[MeSHID:D012063]
Insect Bites[MeSHID:D007299]
Maintenance[MeSHID:D008283]
Glaucoma
Open-Angle[MeSHID:D005902]
Body Weight[MeSHID:D001835]
Heart failure[MeSHID:D006333]
Heart[MeSHID:D006321]
Asthma[MeSHID:D001249]
Accidents[MeSHID:D000059]
Hay fever[MeSHID:D006255]
Mydriasis[MeSHID:D015878]
myometrium[MeSHID:D009215]
Fire - disasters[MeSHID:D005390]
Hemorrhage[MeSHID:D006470]
Serum Sickness[MeSHID:D012713]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Allergic Reaction[MeSHID:D006967]		 0.19 approved,vet_approved agonist
epinephrine alpha-1d adrenergic receptor small molecule NA drugbank , DGIDB Structure of carotid sinus[MeSHID:D002346]
Operative Surgical Procedures[MeSHID:D013514]
Genetic Selection[MeSHID:D012641]
Heart Block[MeSHID:D006327]
Hypersensitivity[MeSHID:D006967]
Cardiac Arrest[MeSHID:D006323]
Angioedema[MeSHID:D000799]
Mucous Membrane[MeSHID:D009092]
Bronchi[MeSHID:D001980]
Shock
Cardiogenic[MeSHID:D012770]
Wheezing[MeSHID:D012135]
Uterine Contraction[MeSHID:D014590]
Rhinitis[MeSHID:D012220]
Urticaria[MeSHID:D014581]
Syncope[MeSHID:D013575]
Dyspnea[MeSHID:D004417]
anaphylaxis[MeSHID:D000707]
Sinusitis[MeSHID:D012852]
Relaxation[MeSHID:D012063]
Insect Bites[MeSHID:D007299]
Maintenance[MeSHID:D008283]
Glaucoma
Open-Angle[MeSHID:D005902]
Body Weight[MeSHID:D001835]
Heart failure[MeSHID:D006333]
Heart[MeSHID:D006321]
Asthma[MeSHID:D001249]
Accidents[MeSHID:D000059]
Hay fever[MeSHID:D006255]
Mydriasis[MeSHID:D015878]
myometrium[MeSHID:D009215]
Fire - disasters[MeSHID:D005390]
Hemorrhage[MeSHID:D006470]
Serum Sickness[MeSHID:D012713]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Allergic Reaction[MeSHID:D006967]		 0.27 approved,vet_approved antagonist
epinephrine alpha-2a adrenergic receptor small molecule NA drugbank , DGIDB Structure of carotid sinus[MeSHID:D002346]
Operative Surgical Procedures[MeSHID:D013514]
Genetic Selection[MeSHID:D012641]
Heart Block[MeSHID:D006327]
Hypersensitivity[MeSHID:D006967]
Cardiac Arrest[MeSHID:D006323]
Angioedema[MeSHID:D000799]
Mucous Membrane[MeSHID:D009092]
Bronchi[MeSHID:D001980]
Shock
Cardiogenic[MeSHID:D012770]
Wheezing[MeSHID:D012135]
Uterine Contraction[MeSHID:D014590]
Rhinitis[MeSHID:D012220]
Urticaria[MeSHID:D014581]
Syncope[MeSHID:D013575]
Dyspnea[MeSHID:D004417]
anaphylaxis[MeSHID:D000707]
Sinusitis[MeSHID:D012852]
Relaxation[MeSHID:D012063]
Insect Bites[MeSHID:D007299]
Maintenance[MeSHID:D008283]
Glaucoma
Open-Angle[MeSHID:D005902]
Body Weight[MeSHID:D001835]
Heart failure[MeSHID:D006333]
Heart[MeSHID:D006321]
Asthma[MeSHID:D001249]
Accidents[MeSHID:D000059]
Hay fever[MeSHID:D006255]
Mydriasis[MeSHID:D015878]
myometrium[MeSHID:D009215]
Fire - disasters[MeSHID:D005390]
Hemorrhage[MeSHID:D006470]
Serum Sickness[MeSHID:D012713]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Allergic Reaction[MeSHID:D006967]		 0.25 approved,vet_approved agonist
epinephrine alpha-2b adrenergic receptor small molecule NA drugbank , DGIDB Structure of carotid sinus[MeSHID:D002346]
Operative Surgical Procedures[MeSHID:D013514]
Genetic Selection[MeSHID:D012641]
Heart Block[MeSHID:D006327]
Hypersensitivity[MeSHID:D006967]
Cardiac Arrest[MeSHID:D006323]
Angioedema[MeSHID:D000799]
Mucous Membrane[MeSHID:D009092]
Bronchi[MeSHID:D001980]
Shock
Cardiogenic[MeSHID:D012770]
Wheezing[MeSHID:D012135]
Uterine Contraction[MeSHID:D014590]
Rhinitis[MeSHID:D012220]
Urticaria[MeSHID:D014581]
Syncope[MeSHID:D013575]
Dyspnea[MeSHID:D004417]
anaphylaxis[MeSHID:D000707]
Sinusitis[MeSHID:D012852]
Relaxation[MeSHID:D012063]
Insect Bites[MeSHID:D007299]
Maintenance[MeSHID:D008283]
Glaucoma
Open-Angle[MeSHID:D005902]
Body Weight[MeSHID:D001835]
Heart failure[MeSHID:D006333]
Heart[MeSHID:D006321]
Asthma[MeSHID:D001249]
Accidents[MeSHID:D000059]
Hay fever[MeSHID:D006255]
Mydriasis[MeSHID:D015878]
myometrium[MeSHID:D009215]
Fire - disasters[MeSHID:D005390]
Hemorrhage[MeSHID:D006470]
Serum Sickness[MeSHID:D012713]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Allergic Reaction[MeSHID:D006967]		 0.27 approved,vet_approved agonist
epinephrine beta-1 adrenergic receptor small molecule NA drugbank , DGIDB Structure of carotid sinus[MeSHID:D002346]
Operative Surgical Procedures[MeSHID:D013514]
Genetic Selection[MeSHID:D012641]
Heart Block[MeSHID:D006327]
Hypersensitivity[MeSHID:D006967]
Cardiac Arrest[MeSHID:D006323]
Angioedema[MeSHID:D000799]
Mucous Membrane[MeSHID:D009092]
Bronchi[MeSHID:D001980]
Shock
Cardiogenic[MeSHID:D012770]
Wheezing[MeSHID:D012135]
Uterine Contraction[MeSHID:D014590]
Rhinitis[MeSHID:D012220]
Urticaria[MeSHID:D014581]
Syncope[MeSHID:D013575]
Dyspnea[MeSHID:D004417]
anaphylaxis[MeSHID:D000707]
Sinusitis[MeSHID:D012852]
Relaxation[MeSHID:D012063]
Insect Bites[MeSHID:D007299]
Maintenance[MeSHID:D008283]
Glaucoma
Open-Angle[MeSHID:D005902]
Body Weight[MeSHID:D001835]
Heart failure[MeSHID:D006333]
Heart[MeSHID:D006321]
Asthma[MeSHID:D001249]
Accidents[MeSHID:D000059]
Hay fever[MeSHID:D006255]
Mydriasis[MeSHID:D015878]
myometrium[MeSHID:D009215]
Fire - disasters[MeSHID:D005390]
Hemorrhage[MeSHID:D006470]
Serum Sickness[MeSHID:D012713]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Allergic Reaction[MeSHID:D006967]		 0.23 approved,vet_approved agonist
epinephrine adrenergic receptor beta-1 NA Successful target TTD , DGIDB Structure of carotid sinus[MeSHID:D002346]
Operative Surgical Procedures[MeSHID:D013514]
Genetic Selection[MeSHID:D012641]
Heart Block[MeSHID:D006327]
Hypersensitivity[MeSHID:D006967]
Cardiac Arrest[MeSHID:D006323]
Angioedema[MeSHID:D000799]
Mucous Membrane[MeSHID:D009092]
Bronchi[MeSHID:D001980]
Shock
Cardiogenic[MeSHID:D012770]
Wheezing[MeSHID:D012135]
Uterine Contraction[MeSHID:D014590]
Rhinitis[MeSHID:D012220]
Urticaria[MeSHID:D014581]
Syncope[MeSHID:D013575]
Dyspnea[MeSHID:D004417]
anaphylaxis[MeSHID:D000707]
Sinusitis[MeSHID:D012852]
Relaxation[MeSHID:D012063]
Insect Bites[MeSHID:D007299]
Maintenance[MeSHID:D008283]
Glaucoma
Open-Angle[MeSHID:D005902]
Body Weight[MeSHID:D001835]
Heart failure[MeSHID:D006333]
Heart[MeSHID:D006321]
Asthma[MeSHID:D001249]
Accidents[MeSHID:D000059]
Hay fever[MeSHID:D006255]
Mydriasis[MeSHID:D015878]
myometrium[MeSHID:D009215]
Fire - disasters[MeSHID:D005390]
Hemorrhage[MeSHID:D006470]
Serum Sickness[MeSHID:D012713]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Allergic Reaction[MeSHID:D006967]		 0.23 approved unknown
epinephrine adrenergic receptor beta-1 NA Successful target TTD , DGIDB Structure of carotid sinus[MeSHID:D002346]
Operative Surgical Procedures[MeSHID:D013514]
Genetic Selection[MeSHID:D012641]
Heart Block[MeSHID:D006327]
Hypersensitivity[MeSHID:D006967]
Cardiac Arrest[MeSHID:D006323]
Angioedema[MeSHID:D000799]
Mucous Membrane[MeSHID:D009092]
Bronchi[MeSHID:D001980]
Shock
Cardiogenic[MeSHID:D012770]
Wheezing[MeSHID:D012135]
Uterine Contraction[MeSHID:D014590]
Rhinitis[MeSHID:D012220]
Urticaria[MeSHID:D014581]
Syncope[MeSHID:D013575]
Dyspnea[MeSHID:D004417]
anaphylaxis[MeSHID:D000707]
Sinusitis[MeSHID:D012852]
Relaxation[MeSHID:D012063]
Insect Bites[MeSHID:D007299]
Maintenance[MeSHID:D008283]
Glaucoma
Open-Angle[MeSHID:D005902]
Body Weight[MeSHID:D001835]
Heart failure[MeSHID:D006333]
Heart[MeSHID:D006321]
Asthma[MeSHID:D001249]
Accidents[MeSHID:D000059]
Hay fever[MeSHID:D006255]
Mydriasis[MeSHID:D015878]
myometrium[MeSHID:D009215]
Fire - disasters[MeSHID:D005390]
Hemorrhage[MeSHID:D006470]
Serum Sickness[MeSHID:D012713]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Allergic Reaction[MeSHID:D006967]		 0.23 approved agonist
epinephrine beta-2 adrenergic receptor small molecule NA drugbank , DGIDB Structure of carotid sinus[MeSHID:D002346]
Operative Surgical Procedures[MeSHID:D013514]
Genetic Selection[MeSHID:D012641]
Heart Block[MeSHID:D006327]
Hypersensitivity[MeSHID:D006967]
Cardiac Arrest[MeSHID:D006323]
Angioedema[MeSHID:D000799]
Mucous Membrane[MeSHID:D009092]
Bronchi[MeSHID:D001980]
Shock
Cardiogenic[MeSHID:D012770]
Wheezing[MeSHID:D012135]
Uterine Contraction[MeSHID:D014590]
Rhinitis[MeSHID:D012220]
Urticaria[MeSHID:D014581]
Syncope[MeSHID:D013575]
Dyspnea[MeSHID:D004417]
anaphylaxis[MeSHID:D000707]
Sinusitis[MeSHID:D012852]
Relaxation[MeSHID:D012063]
Insect Bites[MeSHID:D007299]
Maintenance[MeSHID:D008283]
Glaucoma
Open-Angle[MeSHID:D005902]
Body Weight[MeSHID:D001835]
Heart failure[MeSHID:D006333]
Heart[MeSHID:D006321]
Asthma[MeSHID:D001249]
Accidents[MeSHID:D000059]
Hay fever[MeSHID:D006255]
Mydriasis[MeSHID:D015878]
myometrium[MeSHID:D009215]
Fire - disasters[MeSHID:D005390]
Hemorrhage[MeSHID:D006470]
Serum Sickness[MeSHID:D012713]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Allergic Reaction[MeSHID:D006967]		 0.14 approved,vet_approved agonist
epinephrine tumor necrosis factor small molecule NA drugbank Structure of carotid sinus[MeSHID:D002346]
Operative Surgical Procedures[MeSHID:D013514]
Genetic Selection[MeSHID:D012641]
Heart Block[MeSHID:D006327]
Hypersensitivity[MeSHID:D006967]
Cardiac Arrest[MeSHID:D006323]
Angioedema[MeSHID:D000799]
Mucous Membrane[MeSHID:D009092]
Bronchi[MeSHID:D001980]
Shock
Cardiogenic[MeSHID:D012770]
Wheezing[MeSHID:D012135]
Uterine Contraction[MeSHID:D014590]
Rhinitis[MeSHID:D012220]
Urticaria[MeSHID:D014581]
Syncope[MeSHID:D013575]
Dyspnea[MeSHID:D004417]
anaphylaxis[MeSHID:D000707]
Sinusitis[MeSHID:D012852]
Relaxation[MeSHID:D012063]
Insect Bites[MeSHID:D007299]
Maintenance[MeSHID:D008283]
Glaucoma
Open-Angle[MeSHID:D005902]
Body Weight[MeSHID:D001835]
Heart failure[MeSHID:D006333]
Heart[MeSHID:D006321]
Asthma[MeSHID:D001249]
Accidents[MeSHID:D000059]
Hay fever[MeSHID:D006255]
Mydriasis[MeSHID:D015878]
myometrium[MeSHID:D009215]
Fire - disasters[MeSHID:D005390]
Hemorrhage[MeSHID:D006470]
Serum Sickness[MeSHID:D012713]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Allergic Reaction[MeSHID:D006967]		 NA approved,vet_approved antagonist,agonist
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