Drug-Target Information
Drug Name Target Name Drug Type Target Type Source Drug MeSHID Interaction Score Drug Status Target Action
entrectinib alk tyrosine kinase receptor NA Successful target TTD , DGIDB Operative Surgical Procedures[MeSHID:D013514]
Non-Small Cell Lung Carcinoma[MeSHID:D002289]
Neoplasm Metastasis[MeSHID:D009362]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Malignant Neoplasms[MeSHID:D009369]
Neuroblastoma[MeSHID:D009447]
Colorectal Cancer[MeSHID:D015179]
Mammary Analogue Secretory Carcinoma[MeSHID:D000069295]		 0.11 approved unknown
entrectinib tyrosine-protein kinase jak2 small molecule NA drugbank , DGIDB Operative Surgical Procedures[MeSHID:D013514]
Non-Small Cell Lung Carcinoma[MeSHID:D002289]
Neoplasm Metastasis[MeSHID:D009362]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Malignant Neoplasms[MeSHID:D009369]
Neuroblastoma[MeSHID:D009447]
Colorectal Cancer[MeSHID:D015179]
Mammary Analogue Secretory Carcinoma[MeSHID:D000069295]		 0.01 approved,investigational inhibitor
entrectinib tropomyosin-related kinase a NA Successful target TTD , DGIDB Operative Surgical Procedures[MeSHID:D013514]
Non-Small Cell Lung Carcinoma[MeSHID:D002289]
Neoplasm Metastasis[MeSHID:D009362]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Malignant Neoplasms[MeSHID:D009369]
Neuroblastoma[MeSHID:D009447]
Colorectal Cancer[MeSHID:D015179]
Mammary Analogue Secretory Carcinoma[MeSHID:D000069295]		 0.21 approved unknown
entrectinib high affinity nerve growth factor receptor small molecule NA drugbank , DGIDB Operative Surgical Procedures[MeSHID:D013514]
Non-Small Cell Lung Carcinoma[MeSHID:D002289]
Neoplasm Metastasis[MeSHID:D009362]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Malignant Neoplasms[MeSHID:D009369]
Neuroblastoma[MeSHID:D009447]
Colorectal Cancer[MeSHID:D015179]
Mammary Analogue Secretory Carcinoma[MeSHID:D000069295]		 0.21 approved,investigational inhibitor
entrectinib bdnf/nt-3 growth factors receptor small molecule Successful target TTD , drugbank , DGIDB Operative Surgical Procedures[MeSHID:D013514]
Non-Small Cell Lung Carcinoma[MeSHID:D002289]
Neoplasm Metastasis[MeSHID:D009362]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Malignant Neoplasms[MeSHID:D009369]
Neuroblastoma[MeSHID:D009447]
Colorectal Cancer[MeSHID:D015179]
Mammary Analogue Secretory Carcinoma[MeSHID:D000069295]		 0.22 approved,investigational inhibitor
entrectinib nt-3 growth factor receptor small molecule Successful target TTD , drugbank , DGIDB Operative Surgical Procedures[MeSHID:D013514]
Non-Small Cell Lung Carcinoma[MeSHID:D002289]
Neoplasm Metastasis[MeSHID:D009362]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Malignant Neoplasms[MeSHID:D009369]
Neuroblastoma[MeSHID:D009447]
Colorectal Cancer[MeSHID:D015179]
Mammary Analogue Secretory Carcinoma[MeSHID:D000069295]		 0.35 approved,investigational inhibitor
entrectinib proto-oncogene c-ros NA Successful target TTD , DGIDB Operative Surgical Procedures[MeSHID:D013514]
Non-Small Cell Lung Carcinoma[MeSHID:D002289]
Neoplasm Metastasis[MeSHID:D009362]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Malignant Neoplasms[MeSHID:D009369]
Neuroblastoma[MeSHID:D009447]
Colorectal Cancer[MeSHID:D015179]
Mammary Analogue Secretory Carcinoma[MeSHID:D000069295]		 0.33 approved unknown
entrectinib proto-oncogene tyrosine-protein kinase ros small molecule NA drugbank , DGIDB Operative Surgical Procedures[MeSHID:D013514]
Non-Small Cell Lung Carcinoma[MeSHID:D002289]
Neoplasm Metastasis[MeSHID:D009362]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Malignant Neoplasms[MeSHID:D009369]
Neuroblastoma[MeSHID:D009447]
Colorectal Cancer[MeSHID:D015179]
Mammary Analogue Secretory Carcinoma[MeSHID:D000069295]		 0.33 approved,investigational inhibitor
entrectinib activated cdc42 kinase 1 small molecule NA drugbank , DGIDB Operative Surgical Procedures[MeSHID:D013514]
Non-Small Cell Lung Carcinoma[MeSHID:D002289]
Neoplasm Metastasis[MeSHID:D009362]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Malignant Neoplasms[MeSHID:D009369]
Neuroblastoma[MeSHID:D009447]
Colorectal Cancer[MeSHID:D015179]
Mammary Analogue Secretory Carcinoma[MeSHID:D000069295]		 0.06 approved,investigational unknown
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