| Drug-Target Information | ||||||||
|---|---|---|---|---|---|---|---|---|
| Drug Name | Target Name | Drug Type | Target Type | Source | Drug MeSHID | Interaction Score | Drug Status | Target Action |
| droxidopa | alpha-1a adrenergic receptor | small molecule | NA | drugbank , DGIDB | AMYLOIDOSIS HEREDITARY TRANSTHYRETIN-RELATED[MeSHID:C567782] Hypotension[MeSHID:D007022] Disease[MeSHID:D004194] Amyloid Neuropathies Familial[MeSHID:D028227] Multiple System Atrophy[MeSHID:D019578] Neurogenesis[MeSHID:D055495] Parkinson Disease[MeSHID:D010300] Blood[MeSHID:D001769] Hematological Disease[MeSHID:D006402] Syncope[MeSHID:D013575] Shy-Drager Syndrome[MeSHID:D012791] Dizziness[MeSHID:D004244] Hypotension Orthostatic[MeSHID:D007024] Kidney Diseases[MeSHID:D007674] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
0.44 | approved,investigational | agonist |
| droxidopa | alpha-1b adrenergic receptor | small molecule | NA | drugbank , DGIDB | AMYLOIDOSIS HEREDITARY TRANSTHYRETIN-RELATED[MeSHID:C567782] Hypotension[MeSHID:D007022] Disease[MeSHID:D004194] Amyloid Neuropathies Familial[MeSHID:D028227] Multiple System Atrophy[MeSHID:D019578] Neurogenesis[MeSHID:D055495] Parkinson Disease[MeSHID:D010300] Blood[MeSHID:D001769] Hematological Disease[MeSHID:D006402] Syncope[MeSHID:D013575] Shy-Drager Syndrome[MeSHID:D012791] Dizziness[MeSHID:D004244] Hypotension Orthostatic[MeSHID:D007024] Kidney Diseases[MeSHID:D007674] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
0.51 | approved,investigational | agonist |
| droxidopa | alpha-1d adrenergic receptor | small molecule | NA | drugbank | AMYLOIDOSIS HEREDITARY TRANSTHYRETIN-RELATED[MeSHID:C567782] Hypotension[MeSHID:D007022] Disease[MeSHID:D004194] Amyloid Neuropathies Familial[MeSHID:D028227] Multiple System Atrophy[MeSHID:D019578] Neurogenesis[MeSHID:D055495] Parkinson Disease[MeSHID:D010300] Blood[MeSHID:D001769] Hematological Disease[MeSHID:D006402] Syncope[MeSHID:D013575] Shy-Drager Syndrome[MeSHID:D012791] Dizziness[MeSHID:D004244] Hypotension Orthostatic[MeSHID:D007024] Kidney Diseases[MeSHID:D007674] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational | agonist |
| droxidopa | alpha-2a adrenergic receptor | small molecule | NA | drugbank , DGIDB | AMYLOIDOSIS HEREDITARY TRANSTHYRETIN-RELATED[MeSHID:C567782] Hypotension[MeSHID:D007022] Disease[MeSHID:D004194] Amyloid Neuropathies Familial[MeSHID:D028227] Multiple System Atrophy[MeSHID:D019578] Neurogenesis[MeSHID:D055495] Parkinson Disease[MeSHID:D010300] Blood[MeSHID:D001769] Hematological Disease[MeSHID:D006402] Syncope[MeSHID:D013575] Shy-Drager Syndrome[MeSHID:D012791] Dizziness[MeSHID:D004244] Hypotension Orthostatic[MeSHID:D007024] Kidney Diseases[MeSHID:D007674] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
0.37 | approved,investigational | agonist |
| droxidopa | alpha-2b adrenergic receptor | small molecule | NA | drugbank , DGIDB | AMYLOIDOSIS HEREDITARY TRANSTHYRETIN-RELATED[MeSHID:C567782] Hypotension[MeSHID:D007022] Disease[MeSHID:D004194] Amyloid Neuropathies Familial[MeSHID:D028227] Multiple System Atrophy[MeSHID:D019578] Neurogenesis[MeSHID:D055495] Parkinson Disease[MeSHID:D010300] Blood[MeSHID:D001769] Hematological Disease[MeSHID:D006402] Syncope[MeSHID:D013575] Shy-Drager Syndrome[MeSHID:D012791] Dizziness[MeSHID:D004244] Hypotension Orthostatic[MeSHID:D007024] Kidney Diseases[MeSHID:D007674] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
0.45 | approved,investigational | agonist |
| droxidopa | alpha-2c adrenergic receptor | small molecule | NA | drugbank , DGIDB | AMYLOIDOSIS HEREDITARY TRANSTHYRETIN-RELATED[MeSHID:C567782] Hypotension[MeSHID:D007022] Disease[MeSHID:D004194] Amyloid Neuropathies Familial[MeSHID:D028227] Multiple System Atrophy[MeSHID:D019578] Neurogenesis[MeSHID:D055495] Parkinson Disease[MeSHID:D010300] Blood[MeSHID:D001769] Hematological Disease[MeSHID:D006402] Syncope[MeSHID:D013575] Shy-Drager Syndrome[MeSHID:D012791] Dizziness[MeSHID:D004244] Hypotension Orthostatic[MeSHID:D007024] Kidney Diseases[MeSHID:D007674] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
0.38 | approved,investigational | agonist |
| droxidopa | beta-1 adrenergic receptor | small molecule | NA | drugbank , DGIDB | AMYLOIDOSIS HEREDITARY TRANSTHYRETIN-RELATED[MeSHID:C567782] Hypotension[MeSHID:D007022] Disease[MeSHID:D004194] Amyloid Neuropathies Familial[MeSHID:D028227] Multiple System Atrophy[MeSHID:D019578] Neurogenesis[MeSHID:D055495] Parkinson Disease[MeSHID:D010300] Blood[MeSHID:D001769] Hematological Disease[MeSHID:D006402] Syncope[MeSHID:D013575] Shy-Drager Syndrome[MeSHID:D012791] Dizziness[MeSHID:D004244] Hypotension Orthostatic[MeSHID:D007024] Kidney Diseases[MeSHID:D007674] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
0.35 | approved,investigational | agonist |
| droxidopa | beta-2 adrenergic receptor | small molecule | NA | drugbank , DGIDB | AMYLOIDOSIS HEREDITARY TRANSTHYRETIN-RELATED[MeSHID:C567782] Hypotension[MeSHID:D007022] Disease[MeSHID:D004194] Amyloid Neuropathies Familial[MeSHID:D028227] Multiple System Atrophy[MeSHID:D019578] Neurogenesis[MeSHID:D055495] Parkinson Disease[MeSHID:D010300] Blood[MeSHID:D001769] Hematological Disease[MeSHID:D006402] Syncope[MeSHID:D013575] Shy-Drager Syndrome[MeSHID:D012791] Dizziness[MeSHID:D004244] Hypotension Orthostatic[MeSHID:D007024] Kidney Diseases[MeSHID:D007674] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
0.35 | approved,investigational | agonist |
| droxidopa | beta-3 adrenergic receptor | small molecule | NA | drugbank , DGIDB | AMYLOIDOSIS HEREDITARY TRANSTHYRETIN-RELATED[MeSHID:C567782] Hypotension[MeSHID:D007022] Disease[MeSHID:D004194] Amyloid Neuropathies Familial[MeSHID:D028227] Multiple System Atrophy[MeSHID:D019578] Neurogenesis[MeSHID:D055495] Parkinson Disease[MeSHID:D010300] Blood[MeSHID:D001769] Hematological Disease[MeSHID:D006402] Syncope[MeSHID:D013575] Shy-Drager Syndrome[MeSHID:D012791] Dizziness[MeSHID:D004244] Hypotension Orthostatic[MeSHID:D007024] Kidney Diseases[MeSHID:D007674] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
1.05 | approved,investigational | agonist |
| droxidopa | phenylalanine-4-hydroxylase | small molecule | NA | drugbank | AMYLOIDOSIS HEREDITARY TRANSTHYRETIN-RELATED[MeSHID:C567782] Hypotension[MeSHID:D007022] Disease[MeSHID:D004194] Amyloid Neuropathies Familial[MeSHID:D028227] Multiple System Atrophy[MeSHID:D019578] Neurogenesis[MeSHID:D055495] Parkinson Disease[MeSHID:D010300] Blood[MeSHID:D001769] Hematological Disease[MeSHID:D006402] Syncope[MeSHID:D013575] Shy-Drager Syndrome[MeSHID:D012791] Dizziness[MeSHID:D004244] Hypotension Orthostatic[MeSHID:D007024] Kidney Diseases[MeSHID:D007674] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] |
NA | approved,investigational | inhibitor |
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