Drug-Target Information
Drug Name Target Name Drug Type Target Type Source Drug MeSHID Interaction Score Drug Status Target Action
desipramine alpha-1 adrenergic receptors small molecule NA drugbank Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 NA approved,investigational antagonist
desipramine alpha-1 adrenergic receptors small molecule NA drugbank Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 NA approved,investigational antagonist
desipramine alpha-1 adrenergic receptors small molecule NA drugbank Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 NA approved,investigational antagonist
desipramine alpha-2 adrenergic receptors small molecule NA drugbank Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 NA approved,investigational binder
desipramine alpha-2 adrenergic receptors small molecule NA drugbank Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 NA approved,investigational binder
desipramine alpha-2 adrenergic receptors small molecule NA drugbank Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 NA approved,investigational binder
desipramine beta-1 adrenergic receptor small molecule NA drugbank , DGIDB Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 0.3 approved,investigational other
desipramine beta-2 adrenergic receptor small molecule NA drugbank , DGIDB Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 0.2 approved,investigational antagonist
desipramine muscarinic acetylcholine receptor m1 small molecule NA drugbank , DGIDB Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 0.18 approved,investigational antagonist
desipramine muscarinic acetylcholine receptor m2 small molecule NA drugbank , DGIDB Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 0.24 approved,investigational antagonist
desipramine muscarinic acetylcholine receptor m3 small molecule NA drugbank Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 NA approved,investigational antagonist
desipramine muscarinic acetylcholine receptor m4 small molecule NA drugbank Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 NA approved,investigational antagonist
desipramine muscarinic acetylcholine receptor m5 small molecule NA drugbank Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 NA approved,investigational antagonist
desipramine dopamine d2 receptor small molecule NA drugbank Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 NA approved,investigational binder
desipramine histamine h1 receptor small molecule NA drugbank , DGIDB Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 0.1 approved,investigational antagonist
desipramine 5-hydroxytryptamine receptor 1a small molecule NA drugbank Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 NA approved,investigational binder
desipramine 5-hydroxytryptamine receptor 2a small molecule NA drugbank Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 NA approved,investigational antagonist
desipramine 5-hydroxytryptamine receptor 2c small molecule NA drugbank Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 NA approved,investigational binder
desipramine sodium-dependent noradrenaline transporter small molecule NA drugbank , DGIDB Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 1.06 approved,investigational inhibitor
desipramine norepinephrine transporter NA Successful target TTD , DGIDB Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 1.06 approved unknown
desipramine norepinephrine transporter NA Successful target TTD , DGIDB Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 1.06 approved inhibitor
desipramine sodium-dependent serotonin transporter small molecule NA drugbank , DGIDB Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 0.54 approved,investigational inhibitor
desipramine sphingomyelin phosphodiesterase small molecule NA drugbank Peripheral Neuropathy[MeSHID:D010523]
Disease Management[MeSHID:D019468]
Depressive Syndrome[MeSHID:D003866]
Attention deficit hyperactivity disorder[MeSHID:D001289]
Neoplasm Metastasis[MeSHID:D009362]
Panic Disorder[MeSHID:D016584]
Anxiety Disorders[MeSHID:D001008]
Anxiety[MeSHID:D001007]
Chronic pain[MeSHID:D059350]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Depressive disorder[MeSHID:D003866]
Mental Depression[MeSHID:D003863]		 NA approved,investigational inhibitor
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