Drug-Target Information

Drug-Target Information
Drug Name	Target Name	Drug Type	Target Type	Source	Drug MeSHID	Interaction Score	Drug Status	Target Action
bupropion	neuronal acetylcholine receptor subunit alpha-3	small molecule	NA	drugbank	Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Bipolar Disorder[MeSHID:D001714] Unipolar Depression[MeSHID:D003866] Hypertensive disease[MeSHID:D006973] Disease[MeSHID:D004194] Attention deficit hyperactivity disorder[MeSHID:D001289] Diet therapy[MeSHID:D004035] Weight Gain[MeSHID:D015430] Body Weight[MeSHID:D001835] Diabetes Mellitus Non-Insulin-Dependent[MeSHID:D003924] Seasonal Affective Disorder[MeSHID:D016574] Cessation of smoking[MeSHID:D016540] Mood (psychological function)[MeSHID:D000339] Obesity[MeSHID:D009765] Off-Label Use[MeSHID:D056687] Overweight[MeSHID:D050177] Dyslipidemias[MeSHID:D050171] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] emotional dependency[MeSHID:D003858] Smoking[MeSHID:D012907] Tobacco smoking behavior[MeSHID:D000073869]	NA	approved	antagonist
bupropion	5-hydroxytryptamine receptor 3a	small molecule	NA	drugbank	Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Bipolar Disorder[MeSHID:D001714] Unipolar Depression[MeSHID:D003866] Hypertensive disease[MeSHID:D006973] Disease[MeSHID:D004194] Attention deficit hyperactivity disorder[MeSHID:D001289] Diet therapy[MeSHID:D004035] Weight Gain[MeSHID:D015430] Body Weight[MeSHID:D001835] Diabetes Mellitus Non-Insulin-Dependent[MeSHID:D003924] Seasonal Affective Disorder[MeSHID:D016574] Cessation of smoking[MeSHID:D016540] Mood (psychological function)[MeSHID:D000339] Obesity[MeSHID:D009765] Off-Label Use[MeSHID:D056687] Overweight[MeSHID:D050177] Dyslipidemias[MeSHID:D050171] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] emotional dependency[MeSHID:D003858] Smoking[MeSHID:D012907] Tobacco smoking behavior[MeSHID:D000073869]	NA	approved	negative modulator
bupropion	sodium-dependent noradrenaline transporter	small molecule	NA	drugbank , DGIDB	Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Bipolar Disorder[MeSHID:D001714] Unipolar Depression[MeSHID:D003866] Hypertensive disease[MeSHID:D006973] Disease[MeSHID:D004194] Attention deficit hyperactivity disorder[MeSHID:D001289] Diet therapy[MeSHID:D004035] Weight Gain[MeSHID:D015430] Body Weight[MeSHID:D001835] Diabetes Mellitus Non-Insulin-Dependent[MeSHID:D003924] Seasonal Affective Disorder[MeSHID:D016574] Cessation of smoking[MeSHID:D016540] Mood (psychological function)[MeSHID:D000339] Obesity[MeSHID:D009765] Off-Label Use[MeSHID:D056687] Overweight[MeSHID:D050177] Dyslipidemias[MeSHID:D050171] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] emotional dependency[MeSHID:D003858] Smoking[MeSHID:D012907] Tobacco smoking behavior[MeSHID:D000073869]	0.69	approved	inhibitor
bupropion	norepinephrine transporter	NA	Successful target	TTD , DGIDB	Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Bipolar Disorder[MeSHID:D001714] Unipolar Depression[MeSHID:D003866] Hypertensive disease[MeSHID:D006973] Disease[MeSHID:D004194] Attention deficit hyperactivity disorder[MeSHID:D001289] Diet therapy[MeSHID:D004035] Weight Gain[MeSHID:D015430] Body Weight[MeSHID:D001835] Diabetes Mellitus Non-Insulin-Dependent[MeSHID:D003924] Seasonal Affective Disorder[MeSHID:D016574] Cessation of smoking[MeSHID:D016540] Mood (psychological function)[MeSHID:D000339] Obesity[MeSHID:D009765] Off-Label Use[MeSHID:D056687] Overweight[MeSHID:D050177] Dyslipidemias[MeSHID:D050171] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] emotional dependency[MeSHID:D003858] Smoking[MeSHID:D012907] Tobacco smoking behavior[MeSHID:D000073869]	0.69	approved	unknown
bupropion	norepinephrine transporter	NA	Successful target	TTD , DGIDB	Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Bipolar Disorder[MeSHID:D001714] Unipolar Depression[MeSHID:D003866] Hypertensive disease[MeSHID:D006973] Disease[MeSHID:D004194] Attention deficit hyperactivity disorder[MeSHID:D001289] Diet therapy[MeSHID:D004035] Weight Gain[MeSHID:D015430] Body Weight[MeSHID:D001835] Diabetes Mellitus Non-Insulin-Dependent[MeSHID:D003924] Seasonal Affective Disorder[MeSHID:D016574] Cessation of smoking[MeSHID:D016540] Mood (psychological function)[MeSHID:D000339] Obesity[MeSHID:D009765] Off-Label Use[MeSHID:D056687] Overweight[MeSHID:D050177] Dyslipidemias[MeSHID:D050171] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] emotional dependency[MeSHID:D003858] Smoking[MeSHID:D012907] Tobacco smoking behavior[MeSHID:D000073869]	0.69	approved	inhibitor
bupropion	sodium-dependent dopamine transporter	small molecule	NA	drugbank , DGIDB	Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Bipolar Disorder[MeSHID:D001714] Unipolar Depression[MeSHID:D003866] Hypertensive disease[MeSHID:D006973] Disease[MeSHID:D004194] Attention deficit hyperactivity disorder[MeSHID:D001289] Diet therapy[MeSHID:D004035] Weight Gain[MeSHID:D015430] Body Weight[MeSHID:D001835] Diabetes Mellitus Non-Insulin-Dependent[MeSHID:D003924] Seasonal Affective Disorder[MeSHID:D016574] Cessation of smoking[MeSHID:D016540] Mood (psychological function)[MeSHID:D000339] Obesity[MeSHID:D009765] Off-Label Use[MeSHID:D056687] Overweight[MeSHID:D050177] Dyslipidemias[MeSHID:D050171] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] emotional dependency[MeSHID:D003858] Smoking[MeSHID:D012907] Tobacco smoking behavior[MeSHID:D000073869]	0.87	approved	inhibitor
bupropion	serotonin transporter	NA	Successful target	TTD , DGIDB	Major Depressive Disorder[MeSHID:D003865] Disease Management[MeSHID:D019468] Bipolar Disorder[MeSHID:D001714] Unipolar Depression[MeSHID:D003866] Hypertensive disease[MeSHID:D006973] Disease[MeSHID:D004194] Attention deficit hyperactivity disorder[MeSHID:D001289] Diet therapy[MeSHID:D004035] Weight Gain[MeSHID:D015430] Body Weight[MeSHID:D001835] Diabetes Mellitus Non-Insulin-Dependent[MeSHID:D003924] Seasonal Affective Disorder[MeSHID:D016574] Cessation of smoking[MeSHID:D016540] Mood (psychological function)[MeSHID:D000339] Obesity[MeSHID:D009765] Off-Label Use[MeSHID:D056687] Overweight[MeSHID:D050177] Dyslipidemias[MeSHID:D050171] Disruptive Impulse Control and Conduct Disorders[MeSHID:D007174] emotional dependency[MeSHID:D003858] Smoking[MeSHID:D012907] Tobacco smoking behavior[MeSHID:D000073869]	0.13	approved	unknown
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