Drug-Target Information
Drug Name Target Name Drug Type Target Type Source Drug MeSHID Interaction Score Drug Status Target Action
amitriptyline alpha-1a adrenergic receptor small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved antagonist,inhibitor
amitriptyline alpha-1b adrenergic receptor small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved antagonist
amitriptyline alpha-1d adrenergic receptor small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved antagonist
amitriptyline alpha-2a adrenergic receptor small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved antagonist,agonist
amitriptyline muscarinic acetylcholine receptor small molecule NA drugbank , DGIDB Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 0.14 approved ligand,antagonist
amitriptyline muscarinic acetylcholine receptor small molecule NA drugbank , DGIDB Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 0.08 approved ligand,antagonist
amitriptyline muscarinic acetylcholine receptor small molecule NA drugbank , DGIDB Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 0.06 approved ligand,antagonist
amitriptyline muscarinic acetylcholine receptor small molecule NA drugbank , DGIDB Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 0.11 approved ligand,antagonist
amitriptyline muscarinic acetylcholine receptor small molecule NA drugbank , DGIDB Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 0.1 approved ligand,antagonist
amitriptyline histamine h1 receptor small molecule NA drugbank , DGIDB Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 0.08 approved antagonist
amitriptyline histamine h2 receptor small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved blocker
amitriptyline histamine h4 receptor small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved binder
amitriptyline 5-hydroxytryptamine receptor 1a small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved inhibitor,inducer
amitriptyline 5-hydroxytryptamine receptor 1b small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved binder
amitriptyline 5-hydroxytryptamine receptor 1d small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved binder
amitriptyline 5-hydroxytryptamine receptor 2a small molecule NA drugbank , DGIDB Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 0.07 approved antagonist
amitriptyline 5-hydroxytryptamine receptor 2c small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved antagonist
amitriptyline 5-hydroxytryptamine receptor 6 small molecule NA drugbank , DGIDB Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 0.22 approved antagonist
amitriptyline 5-hydroxytryptamine receptor 7 small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved antagonist
amitriptyline potassium voltage-gated channel subfamily a member 1 small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved inhibitor
amitriptyline herg human cardiac k+ channel small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved blocker
amitriptyline herg human cardiac k+ channel small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved blocker
amitriptyline herg human cardiac k+ channel small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved blocker
amitriptyline potassium voltage-gated channel subfamily kqt member 2 small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved inhibitor
amitriptyline potassium voltage-gated channel subfamily kqt member 3 small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved inhibitor
amitriptyline high affinity nerve growth factor receptor small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved agonist,activator
amitriptyline bdnf/nt-3 growth factors receptor small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved agonist
amitriptyline delta-type opioid receptor small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved agonist
amitriptyline kappa-type opioid receptor small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved agonist
amitriptyline mu-type opioid receptor small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved binder
amitriptyline sigma non-opioid intracellular receptor 1 small molecule NA drugbank Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 NA approved agonist
amitriptyline norepinephrine transporter NA Successful target TTD , DGIDB Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 0.39 approved unknown
amitriptyline sodium-dependent noradrenaline transporter small molecule NA drugbank , DGIDB Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 0.39 approved inhibitor
amitriptyline norepinephrine transporter NA Successful target TTD , DGIDB Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 0.39 approved inhibitor
amitriptyline serotonin transporter NA Successful target TTD , DGIDB Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 0.59 approved unknown
amitriptyline sodium-dependent serotonin transporter small molecule NA drugbank , DGIDB Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 0.59 approved inhibitor
amitriptyline serotonin transporter NA Successful target TTD , DGIDB Urinary Incontinence[MeSHID:D014549]
Disease Management[MeSHID:D019468]
Major Depressive Disorder[MeSHID:D003865]
Unipolar Depression[MeSHID:D003866]
Disease[MeSHID:D004194]
Bedwetting[MeSHID:D053206]
Fibromyalgia[MeSHID:D005356]
Tension Headache[MeSHID:D018781]
Enuresis[MeSHID:D004775]
Irritable Bowel Syndrome[MeSHID:D043183]
Sleep Disorders[MeSHID:D012893]
Spina Bifida[MeSHID:D016135]
Diabetic Neuropathies[MeSHID:D003929]
Sleeplessness[MeSHID:D007319]
Migraine Disorders[MeSHID:D008881]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Mental Depression[MeSHID:D003863]
Depressive disorder[MeSHID:D003866]		 0.59 approved inhibitor
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