Drug-Target Information
Drug Name Target Name Drug Type Target Type Source Drug MeSHID Interaction Score Drug Status Target Action
aminoglutethimide cholesterol desmolase NA Successful target TTD , DGIDB Malignant neoplasm of breast[MeSHID:D001943]
Cushing Syndrome[MeSHID:D003480]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Pituitary-dependent Cushing's disease[MeSHID:D047748]		 22.73 approved unknown
aminoglutethimide cholesterol side-chain cleavage enzyme, mitochondrial small molecule NA drugbank , DGIDB Malignant neoplasm of breast[MeSHID:D001943]
Cushing Syndrome[MeSHID:D003480]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Pituitary-dependent Cushing's disease[MeSHID:D047748]		 22.73 approved,investigational inhibitor
aminoglutethimide cholesterol desmolase NA Successful target TTD , DGIDB Malignant neoplasm of breast[MeSHID:D001943]
Cushing Syndrome[MeSHID:D003480]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Pituitary-dependent Cushing's disease[MeSHID:D047748]		 22.73 approved inhibitor
aminoglutethimide cytochrome p450 19a1 small molecule NA drugbank , DGIDB Malignant neoplasm of breast[MeSHID:D001943]
Cushing Syndrome[MeSHID:D003480]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Pituitary-dependent Cushing's disease[MeSHID:D047748]		 3.54 approved,investigational inhibitor
aminoglutethimide aromatase NA Successful target TTD , DGIDB Malignant neoplasm of breast[MeSHID:D001943]
Cushing Syndrome[MeSHID:D003480]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Pituitary-dependent Cushing's disease[MeSHID:D047748]		 3.54 approved inhibitor
aminoglutethimide aromatase NA Successful target TTD , DGIDB Malignant neoplasm of breast[MeSHID:D001943]
Cushing Syndrome[MeSHID:D003480]
Disruptive
Impulse Control
and Conduct Disorders[MeSHID:D007174]
Pituitary-dependent Cushing's disease[MeSHID:D047748]		 3.54 approved unknown
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